簡介
本實驗室論文發表專注於人工智慧與影像分析，主要的應用層面為醫學影像相關問題。過去的研究中，涵蓋多個領域，包括心肌T1映射技術的改進、腦部結構的自動分割。在深度學習方面，我們致力於開發高效的影像分割與分類模型。例如，針對胸部X光影像中的肺部不透明區域，我們提出了一種基於深度學習的分類方法，通過批次控制和靈敏度調節，提高了模型的準確性和穩定性。此外，我們還開發了基於U-Net架構的模型，實現了對腦部MRI影像的快速精確分割，為擴散影像分析提供了可靠的工具。
在心肌T1映射技術的改進上，我們提出了結合生成對抗網路（GAN）和深度學習對位網路的方法，生成穩定且一致的虛擬MOLLI影像作為對位目標，從而提高了影像對位的準確性，減少了運動偽影對T1映射的影響。這一方法在臨床診斷和監測心臟疾病方面具有潛在的應用價值。在腦部結構的自動分割領域，我們開發了多種基於深度學習的模型，如ASEG、WMP和DKT模型，實現了對腦部MRI影像的自動分割。這些模型不僅提高了分割的準確性，還顯著減少了分析所需的時間，為腦部結構的詳細分析提供了有效的工具。
期刊論文 Journal Articles:
1.Chiu IM, Huang TY, Ouyang D, Lin WC, Pan YJ, Lu CY, Kuo KH (2024) “PACT-3D, a Deep Learning Algorithm for Pneumoperitoneum Detection in Abdominal CT Scans.”, Nature Communications 2024 15: 9660
2. Wang HC, Chen CS, Kuo CC, Huang TY, Kuo KH, Chuang TC, Lin YR, Chung HW (2024) “Comparative Assessment of Established and Deep Learning Segmentation Methods for Hippocampal Volume Estimation in Brain MRI Analysis” NMR in Biomedicine. 2024;e5169.
3. Pan NY, Huang TY, Yu JJ, Peng HH, Chuang TC, Lin YR, Chung HW, Wu MT (2024) “Virtual MOLLI Target: Generative Adversarial Networks towards Improved Motion Correction in MRI Myocardial T1 Mapping”, Journal of Magnetic Resonance Imaging 2024 Apr 2.
4. Li YH, Lin SC, Chung HW, Chang CC, Peng HH, Huang TY, Shen WCn, Tsai CH, Lo YC, Lee TY, Juan CH, Juan CE, Chang HC, Liu YJ, Juan CJ (2023) “The role of input imaging combination and ADC threshold on segmentation of acute ischemic stroke lesion using U-Net.” European Radiology (2023) Sep;33(9):6157-6167.
5. Weng JS, Huang TY (2023), “Deriving a robust deep-learning model for subcortical brain segmentation by using a large-scale database: Preprocessing, reproducibility, and accuracy of volume estimation”, NMR in Biomedicine 2023 May;36(5):e4880.
6. Yu CY, Huang TY, Chung HW (2023), “Single Breath-hold MR T1 Mapping in the Heart: Hybrid MOLLI Combining Saturation and Inversion Recovery”, Magnetic Resonance Imaging 2023 Feb;96:85-92.
7. I-Yun Chang, Huang TY (2022) “Deep learning-based classification for lung opacities in chest x-ray radiographs through batch control and sensitivity regulation”, Scientific Reports, volume 12, Article number: 17597 (2022)
8. Juan CJ, Lin SC, Li YH, Chang CC, Jeng YH, Peng HH, Huang TY, Chung HW, Shen WC, Tsai CH, Chang RF, Liu YJ (2022) “Improving interobserver agreement and performance of deep learning models for segmenting acute ischemic stroke by combining DWI with optimized ADC thresholds” European Radiology.
9. Juan CJ, Huang TY, Liu YJ, Shen WC, Wang CW, Hsu K, Shin N, Chang RF (2022), “Improving Diagnosing Performance for Malignant Parotid Gland Tumors using Machine Learning with Multi-features Based on Diffusion-weighted Magnetic Resonance Imaging”, NMR in Biomedicine 2022 Mar;35(3):e4642.
10. Tsai PR, Chen KH, Hong TM, Wang FN, Huang TY (2021), “Categorizing SHR and WKY rats by chi2 algorithm and decision tree”, Scientific Reports volume 11, Article number: 3463 (2021)
11. Chang YJ, Huang TY, Liu YJ, Chung HW, Juan CJ (2020) “Classification of parotid gland tumors by using multimodal MRI and deep learning”, NMR in Biomedicine, 04 September 2020
12. Chen CH, Yang PC, Wu MT, Chuang TC, Huang TY (2019) “Deriving and validating biomarkers associated with autism spectrum disorders from a large-scale resting-state database”, Scientific Reports, volume 9, Article number: 9043 (2019)
13. Tsai PH, Chen YC, Chiang SW, Huang TY, Chou MC, Liu HS, Chung HW, Chung HW, Peng GS, Ma HI, Kao HW, Chen CY (2018) “Changes in sensorimotor-related thalamic diffusion properties and cerebrospinal fluid hydrodynamics predict gait responses to tap test in idiopathic normal-pressure hydrocephalus”, European Radiology.
14. Huang HH, Huang CY, Chen CN, Wang YW, Huang TY (2018) “Automatic regional analysis of myocardial native T1 values: left ventricle segmentation and AHA parcellations” International Journal of Cardiovascular Imaging 2018 Jan;34(1):131-140.
15. Huang SM, Wu YL, Peng SL, Peng HH, Huang TY, Ho KC, Wang FN. (2016) “Inter-Strain Differences in Default Mode Network: A Resting State fMRI Study on Spontaneously Hypertensive Rat and Wistar Kyoto Rat.” Scientific Reports 2016 Feb 22;6:21697.
16. Tseng YS, Huang TY, Tsai SY (2015) “Reducing signal loss of the parahippocampal gyrus improves imaging of the default-mode network in 3.0-T MRI: the effect of susceptibility-induced field gradients.” NMR in Biomedicine. 2015 Dec; 28(12):1739-1746.
17. Liu YJ, Lee YH, Chang HC, Huang TY, Chiu HC, Wang CW, Chiou TW, Hsu K, Juan CJ, Huang GS, Hsu HH (2015) “A potential risk of overestimating apparent diffusion coefficient in parotid glands.” PLoS One. 2015 Apr 29;10(4):e0124118.
18. Yeh CJ, Tseng YS, Lin YR, Tsai SY, Wang FN, Huang TY (2015) “Resting-State Functional Magnetic Resonance Imaging: The Impact of Regression Analysis" Journal of Neuroimaging. 2015 Jan-Feb;25(1):117-23.
19. Juan CJ, Liu YJ, Huang TY, Chen CY, Huang GS (2014) “Measuring Steady-State Cerebral Vasomotor Reactivity using Non-Triggered Phase-Contrast Magnetic Resonance Imaging” Magnetic Resonance Imaging 2014 Jun;32(5):487-90.
20. Huang YC, Huang TY, Chiu HC, Kuo TS, Hsueh CJ, Kao HW, Wang CW, Hsu HH, Juan CJ. (2014) “Transition into Driven Equilibrium Balanced Steady-State Free Precession Image as an Ultrafast Multisection T2-Weighted Image of the Brain Image of the Brain”, American Journal of Neuroradiology.
21. Huang TY, Tseng YS, Chuang TC (2014) “Automatic calibration of trigger delay time for cardiac magnetic resonance imaging” NMR in Biomedicine 2014 April; 27(4):417–424.
22. Wu PH, Cheng CC, Wu ML, Chao TC, Chung HW, Huang TY (2014) “Effects of RF profile on precision of quantitative T2 mapping using dual-echo steady-state acquisition” Magnetic Resonance Imaging, 2014 Jan;32(1):102-6.
23. Wu PH, Tsai PH, Wu ML, Chuang TC, Shih YY, Chung HW, Huang TY (2013) “High spatial resolution brain functional MRI using sub-millimeter balanced steady-state free precession acquisition” Medical Physics 40, 122304 (2013).
24. Chou MC, Huang TY, Chung HW, Hsieh TJ, Chang HC, Chen CY (2013) “Q-ball Imaging with PROPELLER EPI Acquisition”, NMR in Biomedicine 2013 Dec;26(12):1723-32.
25. Tang YW, Huang TY, Wu WC (2013) “Fast and fully automatic calibration of frequency offset for balanced steady-state free precession cardiovascular magnetic resonance at 3.0 Tesla” Journal of Cardiovascular Magnetic Resonance 2013, 15:32.
26. Chang HC, Chuang TC, Lin YR, Wang FN, Huang TY, Chung HW (2013) “Correction of geometric distortion in Propeller echo planar imaging using a modified reversed gradient approach”, Quantitative Imaging in Medicine and Surgery. 2013 April; 3(2): 73–81.
27. Yang YH, Huang TY, Wang FN, Chuang TC, Chen NK (2013) “Accelerating EPI Distortion Correction by Utilizing a Modern GPU-Based Parallel Computation” Journal of Neuroimaging 2013;23:202-206.
28. Lin YR, Tsai SY, Huang TY, Chung HW, Huang YL, Wu FZ, Lin CC, Peng NJ, Wu MT (2013) “Inflow-weighted pulmonary perfusion: Comparison between dynamic contrast-enhanced MRI versus perfusion scintigraphy in complex pulmonary circulation” Journal of Cardiovascular Magnetic Resonance 2013, 15:21.
29. Peng HH, Huang TY, Wang FN, Chung HW (2013) “Flow-gated radial phase-contrast imaging in the presence of weak flow.” International Journal of Cardiovascular Imaging. 2013 Jan;29(1):131-40.
30. Tsai JM, Huang TY, Tseng YS, Lin YR (2012) “Free-Breathing MOLLI: Application to myocardial T1 mapping” Medical Physics 39(12):7291-7302.
31. Liu YJ, Huang TY, Lee YH, Juan CJ (2012) “The Cerebral Vasomotor Response in Varying CO2 Concentrations, as Evaluated using Cine Phase Contrast MRI: flow, volume, and cerebrovascular resistance indices” Medical Physics 2012, 39(11):6534-6541.
32. Wang CC, Huang TY (2012), “Self-gated PROPELLER-encoded cine cardiac imaging”, International Journal of Cardiovascular Imaging. 2012, Aug;28(6): 1477-1485.
33. Huang TY, Yu-Shen Tseng, Yu-Wei Tang, Yi-Ru Lin (2012) “Optimization of PROPELLER reconstruction for free-breathing T1-weighted cardiac imaging”, Medical Physics 2012, 39(8), 4896.
34. Tang YW, Huang TY (2011) “Real-time feedback optimization of z-shim gradient for automatic compensation of susceptibility-induced signal loss in EPI.” Neuroimage, Apr 15;55(4):1587-92.
35. Chen JW, Huang TY, Peng HH, Chen WS, Tseng WY (2011) “Proton resonance frequency shift-weighted imaging for monitoring MR-guided high-intensity focused ultrasound transmissions.” Journal of Magnetic Resonance Imaging. 2011 Jun;33(6):1474-81.
36. Huang TY, Tang YW, Ju SY (2011) “Accelerating image registration of MRI by GPU-based parallel computation.” Magnetic Resonance Imaging 2011 June; 29 (5):712-716.
37. Peng HH, Bauer S., Huang TY, Chung HW, Hennig J., Jung B., Markl M. (2010) “Optimized Parallel Imaging for Dynamic PC-MRI with Multi-Directional Velocity Encoding” Magnetic Resonance in Medicine Aug;64(2):472-80.
38. Chuang TC, Wu MT, Huang TY, Lin YR, Tsai SY, Chang HC, Chung HW (2010) “Stimulated echo induced misestimates on diffusion tensor indices and its remedy” Journal of Magnetic Resonance Imaging 2010 June; 31:1522-1529.
39. Peng HH, Huang TY, Tseng WY, Lin EL, Chung HW, Wu CC, Wang YS, Chen WS (2009) “Simultaneous temperature and magnetization transfer (MT) monitoring during high-intensity focused ultrasound (HIFU) treatment: preliminary investigation on ex vivo porcine muscle.” Journal of Magnetic Resonance Imaging 2009 Sep;30(3):596-605.
40. Liu YJ, Juan CJ, Chen CY, Wang CY, Wu ML, Lo CP, Chou MC, Huang TY, Chang H, Chu CH, Li MH (2007) “Is the fBOLD response dependent on hBOLD signal in the fMRI experiment? Experiments of long-duration hypercapnia and multi-level CO2 concentration.” American Journal of Neuroradiology 28: 1009-1014.
41. Huang TY, Liu YJ, Stemmer A, Brigitte P. (2007) “T2 measurement of the human myocardium using a T2-prepared transient-state TrueFISP sequence” Magnetic Resonance in Medicine 57:960-966.
42. Wu ML, Wu PS, Huang TY, Shih YY, Chou MC, Liu HS, Chung HW, Chen CY (2007) “Frequency stabilization using infinite impulse response filtering for SSFP fMRI at 3T” Magnetic Resonance in Medicine 57:369-379.
43. Chuang TC, Huang TY, Lin FH, Wang FN, Juan CJ, Chung HW, Chen CY, Kwong KK (2006) “PROPELLER-EPI with parallel imaging using a circularly symmetric phase array RF coil at 3.0 T: Application to high resolution diffusion-weighted imaging” Magnetic Resonance in Medicine 56:1352–1358.
44. Tsai SY, Wu MT, Lin YR, Hsieh KS, Lin CC, Huang TY, Chung HW, Pan JY, Huang YL, Pan HB, Yang CF (2006) “Assessment of Complex Pulmonary Circulation in Congenital Heart Disease: Temporal Correlation-based Bolus-Chasing Dynamic Contrast-enhanced MR imaging” Magnetic Resonance in Medicine 56:517–526.
45. Chou MC, Wu ML, Chen CY, Wang CY, Huang TY, Liu YJ, Juan CJ, Chung HW (2006) “TENsor Deflection (TEND) Tractography with adaptive sub-voxel stepping” Journal of Magnetic Resonance Imaging 24:451-458.
46. Wang FN, Huang TY, Lin FH, Chuang TC, Chen NK, Chung HW, Chen CY, Kwong KK (2005) “Propeller EPI: an MR imaging technique suitable for diffusion tensor imaging at high field strength with reduced geometric distortions” Magnetic Resonance in Medicine 54:1232-1240.
47. Lin FH, Huang TY, Chen NK, Wang FN, Stufflebeam SM, Belliveau JW, Wald WW, Kwong KK (2005) “Functional MRI Using Regularized Parallel Imaging Acquisition” Magnetic Resonance in Medicine 54:343-353.
48. Wu ML, Ko CW, Chen TY, Wu MT, Chung HW, Huang TY, Lin YR (2005) “MR Ventriculocisternography By Using 3D Balanced Steady-State Free Precession Imaging: Technical Note” American Journal of Neuroradiology 26:1170-1173.
49. Chou MC, Lin YR, Huang TY, Wang CY, Chung HW, Juan CJ, Chen CY (2005) “FLAIR Diffusion-Tensor MR Tractography: Comparison of Fiber Tracking with Conventional Imaging” American Journal of Neuroradiology 26:591-597.
50. Lin YR, Wu MT, Huang TY, Tsai SY, Chung HW, Mai Vu M, Chen CY, Pan HB (2004) “Comparison of arterial spin labeling and first-pass Gd-DTPA dynamic method for pulmonary perfusion imaging in healthy volunteers: The inflow spin-tracer saturation effect” Magnetic Resonance in Medicine 52:1291–1301.
51. Huang TY, Chung HW, Chen MY, Giiang LH, Chin SC, Lee CS, Chen CY, Liu YJ (2004) “Supratentorial Cerebrospinal Fluid Production Rate in Healthy Adults: Quantification with Two-dimensional Cine Phase-Contrast MR Imaging with High Temporal and Spatial Resolution” Radiology 233: 603-608.
52. Huang TY, Chung HW, Wang FN, Ko CW, Chen CY (2004) “Fat and water separation in balanced steady-state free precession using the Dixon method.” Magnetic Resonance in Medicine 51:243-247.
53. Huang TY, Wu ML, Chiang TY, Lin YD, Chung HW (2003) “Design and Implementation of a Fascimile Electrocardiographic System for Convenient Remote Monitoring.” Bulletin of the College of Engineering, National Taiwan University, No. 88, June 2003, pp. 43-50.
54. Huang TY, Huang IJ, Chen CY, Scheffler K, Chung HW, Cheng HC (2002) “Are TrueFISP images T2/T1-weighted?” Magnetic Resonance in Medicine 48:684-688.
55. Giiang LH, Chen CY, Chen MY, Huang TY, Chung HW (2000) “Normal and Abnormal Cerebrospinal Fluid Dynamics Evaluated by Optimized Cine Phase-contrast MR Imaging” Chinese Journal of Radiology Vol.25, No.5, p.191-195, August 2000.
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